The Mercure Madrid Santo Domingo is housed in a 400 year old building, right in Madrid's historic city center. Madrid has several places of interest to visit, including the Calle de Serrano shopping district, Calle de le Cava Baja, El Rastro Market, Centro de Arte de Reina Sofia, the Plaza Mayor, the Plaza de Oriente, Teatro Real, the Museo del Prado, and the Estadio Santiago Bernabeu. The Madrid International Airport is serviced daily by more than one hundred airlines. Once guests of the Mercure Madrid Santo Domingo are in the city, there are several options for public transportation, as the buses and trains reach all corners of the city. The hotel staff is happy to help with taxi or rental car arrangements.

Each of the 120 rooms at the Mercure Madrid Santo Domingo is uniquely designed and offers comfortable bedding, direct dial phones, satellite television, en suite baths with complimentary toiletries and hair dryers, clock radios, Internet connections, and coffee and tea machines.

There are many amenities available at the Mercure Madrid Santo Domingo, including ample parking, wireless high speed Internet, laundry and dry cleaning facilities, meeting and conference rooms, an onsite restaurant and bar, and a friendly reception staff. Guests will enjoy the beautiful artwork, furniture, and antiques that decorate the museum hotel.